Qandli diabet holatiga ko'ra uzoq ish soatlari va surunkali buyrak kasalligi o'rtasidagi bog'liqlik Ⅱ

NATIJALAR

Tadqiqot populyatsiyasining umumiy xususiyatlari 14,839 jami ishtirokchi DM bo'lmagan guruhga (N ¼ 12,703) va DM guruhiga (N ¼ 2136) bo'lingan. Guruhlar ish vaqti bo'yicha taqqoslandi. DM bo'lmagan guruhda 5851 ishtirokchi ishladi<40 h/week, 3324 participants worked 41 to 52 h/week, and 3528 participants worked >52 soat / hafta. DM guruhida 989 nafar ishtirokchi ishladi<40 h/week, 465 participants worked 41 to 52 h/week, and 682 participants worked >52 soat / hafta.

DM bo'lmagan guruhda ish vaqtiga ko'ra yosh farqi kuzatildi. Ish vaqti ko'proq bo'lgan ishtirokchilar erkaklar ustunlik qiladi va jismoniy faol bo'lish ehtimoli kamroq edi. Bundan tashqari, uzoqroq ish soati guruhlarida hozirgi sigaret chekuvchilar va ichish muammosi bo'lgan ishtirokchilarning nisbati kattaroq edi. Ish vaqti uzoqroq bo'lgan guruhlarda semizlik va gipertenziyaning yuqori tarqalishi kuzatildi. CKD tarqalishi ish soatlari guruhlari orasida farq qilmadi (P ¼ 0.2074).

DM guruhida ish vaqtiga ko'ra yosh farqi kuzatildi. Ish vaqti ko'proq bo'lgan ishtirokchilar odatda erkaklardir. Hozirgi sigaret chekuvchilarning ulushi ish vaqti uzoqroq bo'lgan guruhda yuqori bo'lgan. Ish soatlari guruhlari orasida semizlik va gipertenziya tarqalishida farq kuzatilmadi. Bundan tashqari, hech qanday farq yo'q ediCKD tarqalishiish soatlari guruhlari orasida (P ¼ 0.0977). O'rganilayotgan aholining batafsil umumiy tavsifi 1-jadvalda keltirilgan.

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Qandli diabet holatiga ko'ra ish soatlari va CKD o'rtasidagi bog'liqlik

The association between working hours and CKD is shown in Table 2. The association was assessed according to diabetic status, and the interaction between diabetic status and working hours was also analyzed. The overall P for interaction in the crude model was 0.1584. The P for interaction was 0.0683 in the adjusted model 1 (adjusted for age, sex, educational status, household income, physical activity, smoking and drinking status, obesity, hypertension, worker type, and working schedule). In the crude model, P for interaction was 0.0553 and 0.5105 in the 41 to 52, and >52 h/week groups, respectively, compared with the  40 h/week group. In the adjusted model, there was an interaction effect in the 41 to 52 h/ week group (P ¼ 0.0212) but not in >52 soat/hafta guruhi (P ¼ 0.2490).

The crude model presented the relationship between working hours and CKD without any adjustment. Those working for  40 h/ week were set as the reference group. In participants without DM, the OR of having CKD in the 41 to 52 and >52 h/week groups was 0.85 (95% CI 0.62–1.18, P ¼ 0.3312) and 0.75 (95% CI 0.53–1.05, P ¼ 0.0955), respectively. In those with DM, the OR was 1.44 (95% CI 0.94–2.19, P ¼ 0.0908) in the 41 to 52 h/week group and 0.90 (95% CI 0.59–1.36, P ¼ 0.6080) in the >52 soat / hafta guruhi.

The model after adjusting for covariates including age, sex, educational status, household income, physical activity, smoking and drinking status, obesity, hypertension, and working environment (adjusted model 1) was also analyzed. In the non-DM group, compared with participants who worked  40 h/week, those who worked 41 to 52 h/week showed an OR of 0.92 (95% CI 0.66–1.27, P ¼ 0.6021), and those who worked >52 soat/haftada 0,72 OR ko'rsatdi (95% CI 0,50–1.03, P ¼ 0,0695). DM guruhida haftasiga 41 dan 52 soatgacha bo'lgan guruhda KKD bilan kasallanish ehtimoli 1,85 baravar yuqori (to'g'irlangan OR 1,85, 95% CI 1,15-2,96, P ¼ 0,0112)<40 h/week group. The OR in the >52 soat / hafta guruhi, 4 0 soat / hafta guruhi bilan solishtirganda, 0.97 (95% CI 0.61-1.53, P ¼ 0.8786).

An additional analysis was performed to determine whether there was an association between long working hours and CKD after adjusting for diabetes-related factors. Additional adjustment for the duration of diabetes and control of HbA1c was performed (adjusted model 2). In the adjusted model 2, the OR was 1.92 (95% CI 1.20– 3.08, P ¼ 0.0063) in participants who worked 41 to 52 h/week and 1.01 (95% CI 0.62–1.62, P ¼ 0.9781) in those who worked >52 soat / hafta.

Ko'p ish soati mezonlarida ish soatlari va CKD o'rtasidagi bog'liqlik

Ish vaqti va CKD o'rtasidagi bog'liqlik ko'p ish soati mezonlari bo'yicha tahlil qilindi. Assotsiatsiya diabet bilan og'rigan ishtirokchilarda uch xil ish soati mezonlari asosida tahlil qilindi. Har bir model yosh, jins, ta'lim holati, uy xo'jaligi daromadlari, jismoniy faollik, chekish va ichish holati, semizlik, gipertoniya, ish muhiti va diabet bilan bog'liq omillarni o'z ichiga olgan kovariantlarga moslashtirilgandan so'ng tahlil qilindi.

In criterion 1, participants were classified into those who work  40 h/week, 41 to 60 h/week, >60 h/week. Those working for  40 h/week were set as the reference group. The OR of having CKD in the 41 to 60 h/week group and >60 soat/hafta guruhi 1,61 (95% CI 1.{{10}5–2,47, P ¼ 0,0294) va 0,95 (95% CI 0,53–) edi. 1,68, P ¼ 0,8470), mos ravishda.

In criterion 2, participants were classified into those who work  35 h/week, 36 to 50 h/week, >50 h/week. Those working for  35 h/week were set as the reference group. The OR of having CKD in the 35 to 50 h/week group and >5 0 soat/hafta guruhi 2,27 (95% CI 1,40–3,68, P ¼ 0,0009) va 1,35 (95% CI 0,80–2,27, P ¼ 0,2655), mos ravishda.

3-mezon boʻyicha ishtirokchilar yetti guruhga boʻlingan (haftada 35 soat, haftasiga 36–40 soat, haftada 41–45 soat, haftada 46–50 soat, 51–55 h/hafta, 56–60 soat/hafta va > 60 soat) va haftasiga 35 soat ishlaydiganlar mos yozuvlar guruhi sifatida belgilangan. CKD bo'lgan OR haftasiga 36 dan 40 soatgacha bo'lgan guruhda (tuzatilgan OR 1,91, 95% CI 1,03–3,53, P ¼ 0,0399), 41 dan 45 soatgacha bo'lgan guruhda (tuzatilgan OR 2,77, 91,4% CI) sezilarli darajada yuqori edi. 5.38, P ¼ 0.0026) va 46 dan 50 soatgacha bo'lgan guruh (to'g'rilangan OR 2.50, 95% CI 1.35-4.61, P ¼ 0.0035). Batafsil natijalar 3-jadvalda keltirilgan.