Menopauza surasidagi uyqusizliklarni davolashda an'anaviy xitoylik dori-darmonlar bo'yicha klinik tadqiqotlar
Jan 07, 2025
Menopauza,ham tanilganperimenopum, menopauzadan oldin va keyin vaqtni anglatadi. Bu davrda Ayollardagi ayollar vazifasi asta-sekin pasayadi va gormon darajasini pasaytiradi, bu issiq yonishi, tungi terlar va uyqusizlikka olib keladi, bu menopauza surasidagi ayollar hayotiga jiddiy ta'sir ko'rsatadi. Ular orasida uyqusizlik kasalligi menopauza qariyalarining eng muhim alomatlaridan biri bo'lib, ular uxlab qolish, uyg'onish yoki ko'p orzulardan uyg'onish, yarim tunda uyg'onish, ko'p orzular va osonlik bilan boshpana olishlari mumkin emas.
Yuqori sifatli - bu juda yaxshi ekstrakti ayniqsaMenopauzauza
Uni qanday ishlatish haqida batafsil ma'lumot olish uchun biz bilan bog'laning
Uzoq muddatli uyqu buzilishitanadagi endokrin va asab tizimining buzilishiga olib kelishi mumkin vaQandli diabet xavfini oshiring, gipertenziya,Miyokard infarkti, semizlikvaBoshqa kasalliklar [2].
Tadqiqotlar shuni ko'rsatdiki, menopauza qariyaplarida uyqusizlikning kasalligi yil sayin ortib bordi. 40 yoshdan 65 yoshgacha bo'lgan mamlakatim 46,87% ni tashkil qiladi, bu Evropa va AQShda [3] dan yuqori. Hozirgi vaqtda g'aroyib ayollar menopauzadagi uyqu buzilishini davolash uchun asosiy usullar gormonning almashtirish va jipnozli dorilar va gipnotik moddalardan foydalanish hisoblanadi. Ma'lum bir klinik ta'sir mavjud bo'lsa-da, gormon almashtirish terapiyasi ayollarda saraton kasalligini oshiradi; Saylovlar va gipnotik moddalardan uzoq muddatli foydalanish giyohvand moddalarga chidamliligiga moyil bo'lib, ko'plab salbiy reaktsiyalar, oson tiklanish va uzoq muddatli sur'atlar samarasidir [4].
Holistik tushunchalar va sindromlarning rahbarligi ostida, an'anaviy xitoy tibbiyotini turlicha bo'lib, turli shakllarga ega, ular turlicha bo'lgan, Xitoy tibbiyot massaji va boshqa davolash usullari, kam sharafli reaktsiyalarga ega va ijobiy samaradorlik mavjud. Ular G'arbiy tibbiyotning asosiy davolash bilan hamkorlik qilishi va samaradorlikni oshirish va toksiklikni kamaytirishga ta'sir qilishi mumkin. Ushbu modda menopauza surasidagi uyquni, differentsiatsiyalarni davolash, Xitoy tibbiyotining tashqi kasalligini, xitoy tibbiyotining tashqi kasalligini tashqi davolash, xitoy tibbiyotining tashqi kasalligini tashqi davolash to'g'risidagi tadqiqot holatini qisqacha yakunlaydi va an'anaviy xitoy tibbiyotiga oid klinik davolash.
1. Etiologiya va patogenez
Traditional Chinese medicine does not have a specific record of menopausal sleep disorders, and often classifies them into the categories of "insomnia", "organ dryness", "inability to sleep", "eyes cannot close", etc. in traditional Chinese medicine. "Qon alomatlari va uxlash" shunday deyilgan: "Jigar va uyqusizlikni jigarni saqlaydi. Odam uyg'oq bo'lganda, jon jigarga qaytadi." [5] "Lei Chjeng Ji Cai" deydi: "Fikrlar taloq, taloq qonini xafa qiladi va bir necha yillar davomida uyqusizlik". [6] "Hayotni hurmat qilish kitobi" deydi: "Yurak va o't pufagi ham qo'rqoq, odam osonlikcha ishlamoqda. U juda noaniq tushlar va zaiflik va bezovtalik tufayli uxlay olmaydi." [7] "Oltin kamera zaruratlari va yurak klassikasi" deb aytadi: "Odam uyg'onganida, jonni saqlab qolsa, jigarda saqlanadi, agar jon saqlanmasa, ular uxlay olmaydilar." [8] Yuqoridagi yozuvlar tushkunlik asosan yurak, jigar va taloq bilan bog'liqligini ko'rsatadi. O'zlarining klinik amaliyotiga asoslanib, o'z o'tmishdoshlarining nazariyotlari va tajribalarini umumlashtiradi, keyinchalik shifokorlarning avlodlari keyinchalik menopavaryar uyqu buzilishi bo'lgan etiologiyani o'rganib, o'rgandilar. Professor Vang Ping ushbu kasallikning etiologiyasi bu juda og'ir energiya, hissiyotlarning etishmasligi, yomon jarohatlar, haddan tashqari jarohatlar, haddan tashqari jarohatlar, natijada uyqusizlik yo'qoladi [9].
Jun professori Yunniyo yomonlikning ichki qismiga bostirib kiradi, u quyoshga etib boradi va Yangdan Yang bilan bog'laydi va "Er 10]" ni [10] ga aylantiradi.
Professor Lu Shaoguang klinik amaliyotda, jigar tushkunligi perimenopauzadagi bemorlarda surunkali uyqusizlikning asosiy patogenezidir [11]. Professor Liu Zuyi, menopauza surasi, jigar etishmovchiligi, jigar etishmovchiligi, jigar ishlamay qolishi va taloq va erning bezovtalanishi tufayli ko'pincha uyqusizlikdan aziyat chekmoqda [12]. Professor Zhang Jiyuan, menopauzaoniyaning asosiy sababi - menopauzadagi uyqusizlik yurak va buyrak o'rtasidagi aloqa etishmasligi. Yurak va buyrak suvi va olovi ulanmagan. Buyrak suvi etarli emas, yurak do'zasi yolg'iz, yin va yang u ulanmagan, bu esa ruhni bezovta qiladi va kasallikni keltirib chiqaradi. [13] Professor Zhang Bodi bu kasallik ichki a'zolarning, balg'am, qon stazalarining disfunktsiyasi, asl holatni kuchaytira olmaydigan va buzg'unchi aylanishni shakllantirishga majbur qiladi. Shuning uchun patologik mahsulotlar kam baholanmasligi kerak. [14]
Xulosa qilib aytganda, menopauzadagi uyqu buzilishlarining etiologiyasi va etiketlari asosan Zang-Fu va Yin etishmovchiligi, Yin va Yin etishmasligi tufayli. Menopauza qariyalarining maxsus fiziologik bosqichi tufayli, buyraklar mohiyati pasayadi, shangu va Ranba Meridmans ta'sir qiladi, Yang esa isitilmayapti va oziqlantirilmayapti va ularning vazifalari g'ayritabiiydir. Yin etishmovchiligi va qon etarli emas, balki ruh ishlatilmaydi, qon va tana suyuqliklari balg'am va qon stasisini hosil qilish va bu kasallikni keltirib chiqarmaydi.
2 sindromni farqlash va davolash
Siydiki, menopauzadagi ayollarning uyqu buzilishi, har bir shifokorning o'ziga xos tizimiga ega. Hozirgi vaqtda TCM sindromi turli xil turlari mavjud, bu kasallikning farqlanishi va tasnifi va usullari boshqacha. Klinik usullarning aksariyati klassik retseptlar va o'z-o'zidan ko'rsatmalarini qo'llaydi. Ushbu maqolada adabiyot va tegishli tadqiqotlar bilan tanishish orqali menopauzadagi ayollar uyqu sindromi, jigar tushkunlik sindromi, jigar tushkunlik sindromi, buyrakning etishmovchiligi sindromi, buyrakning etishmovchiligi sindromi, yurak-o't pufagi sindromi.
2.1 Buyrak etishmovchiligi va jigar tushkunlik sindromi
Ji mingzi va boshqalar. [16] Tasodifiy ravishda har bir guruhda 36 ta nazorat guruhi va boshqaruv guruhiga perimenopaulyal kasalligi bo'lgan 72 nafar ikkiga bo'lingan. Davolash guruhiga Liuwei Dihuang tabletkalari va segaoo kukuni, kuniga 1 doz yotqizilgan, yotishdan oldin iliq berildi. Nazorat guruhiga diazepam planshetlari berildi. 5-5 Har safar kuniga bir marta 0 mg; Oryzanol 10-30 Har safar, kuniga 3 marta, og'iz orqali. Ikkala guruh ham 14 kun davomida davolandi. Natijalar davolash guruhining umumiy samarali stavkasi (91,67%) nazorat guruhidan ancha yuqori (69,44%) (P<0.05). Wang Feifeng et al. [17] randomly divided 52 patients with perimenopausal insomnia of kidney deficiency and liver depression into a treatment group and a control group, 26 cases in each group. The treatment group was treated with Ganmai Dazao Decoction, 1 dose per day, decocted in water and taken warm twice; the control group was given estazolam tablets (10 mg once a day) combined with oryzanol (20 mg 3 times a day) orally. After 3 months of treatment, the total effective rate of the treatment group (92.3%) was significantly higher than that of the control group (80.8%) (P<0.01).
Yao Zouing va boshqalar. [18] Tasodifiy ravishda perimenopaulyal uxlamaydigan 113 bemorlarga buyrak etishmovchiligi va jigar tushkunligi davolash guruhi va boshqaruv guruhiga aylanadi. Davrli Yinni oziqlantirish va ruhiy stazliklarni echib, ya'nigulnikolar, ya'nigulniko glipinosa, "Peeonika" ga boylik va ongni tinchlantiruvchi, - deb hisoblash va ongni tinchlantiruvchi, - deb hisoblash va ongni tinchlantiruvchi, - deb hisoblash va ongni tinchlantiruvchi, - deb hisoblash va ongni tinchlantiruvchi, - deb hisoblash va ongni tinchlantiruvchi, - deb hisoblash va ongni tinchlantiruvchi, - deyiladi. Ajratilgan oq panli ildiz, 15 g har bir likrum lyuritum, Zizifus Nyuujuba urug'i, 20 g albribissin po'stlog'i, 30 g ko'pburchak po'stlog'i. Retsept kuniga bitta doz edi, ovqatdan keyin ikki dozaga bo'lingan. Nazorat guruhidagi 53 mg estazolam planshetlariga har kecha yotishdan oldin 30 minutdan olingan. 8 haftalik davolanishdan so'ng, davolanish guruhining umumiy samarali stavkasi (91,7%) nazorat guruhining umumiy (73,5%) (P<0.05); the degree of improvement in hormone levels was significantly better than that of the control group (P<0.05); the TCM syndrome score, Pittsburgh Sleep Quality Index (PSQI) scale score, hot flashes, sweating, sexual pain, headache, palpitations and other symptom scores were significantly lower than those of the control group (P<0.05). The results showed that the Zishen Jieyu Ningxin prescription can effectively improve the various indicators of perimenopausal sleep disorders of kidney deficiency and liver depression type, and has a better efficacy than estazolam tablets. Zhang Ya et al. [19] divided 116 perimenopausal insomnia patients with kidney deficiency and liver depression into a control group and a treatment group using a random number table method, with 58 cases in each group.
Nazorat guruhi og'zaki estazolam planshetlari, har safar kuniga bir marta; Davolash guruhiga Songyu Yinxu retsepti (10 G ning har biri 1 gekoforii, sitrus gifantium, sitrus gifantium, Cortcuma laktame, Cortcuma Arommatia, Cortcuma Arommatia, Rizoma Alismatis, 6 g qizilmiyasi) Boshqarish guruhining davolash usuli, kuniga 1 doz, ertalab va kechqurun ikki marta. 4 haftalik davolanishdan so'ng, PSQI shkalasi, o'zini o'zi baholash depressiya shkalasi (SAS) va davolash guruhidagi belgilar va davolash guruhidagi belgilar va davolash guruhidagi belgilar nazorat guruhiga (p<0.05), and the scores of 8 quality of life items and serum estradiol (E2) level were significantly higher than those in the control group (P<0.05). The results showed that Songyu Yinxu prescription combined with estazolam tablets was superior to estazolam tablets alone in improving sleep quality, alleviating depression and anxiety, and improving clinical symptoms in the treatment of perimenopausal insomnia with kidney deficiency and liver depression. Li Ying et al. [20] randomly divided 103 patients with perimenopausal insomnia of kidney deficiency and liver depression into a control group and a treatment group. The control group received estazolam tablets, and the treatment group received Chaihu Jia Longgu Muli Decoction combined with auricular acupoint pressing on the basis of the treatment method of the control group. Both groups took 7 days as one course of treatment, and a total of 3 courses of treatment were given. Results After treatment, the PSQI, SDS, SAS scores and TCM symptom scores of the treatment group were significantly lower than those of the control group (P < 0.05); the serum 5-hydroxytryptamine (5-HT) and dopamine (DA) levels were significantly higher than those of the control group (P < 0.05). This indicates that Chaihu Jia Longgu Muli Decoction, auricular acupoint pressing beans combined with estazolam tablets can improve the sleep quality of perimenopausal insomnia patients with kidney deficiency and liver depression, and the efficacy is better than that of simple estazolam tablets.
2.2 Yurakbary yahudiy taassam
Qiao Veyo va boshqalar. [21] Tasodifiy ravishda perimenopauza gipertenziya gipertenziyasi va uyqusizlik bilan bog'liq 60 ta bemorni boshqaruv guruhi va davolash guruhiga aylantirdi, har bir guruhda 30 ta holat. Boshqarish guruhi kuniga bir marta, kuniga bir marta, yotishdan oldin kuniga 2 mg bilan davolandi; Davolash guruhi Tianwang Buxin Dan va Jiiotai Wan va Minus tabletkalari bilan davolangan, 3-4 00 da, soat 200 ml.
4 haftalik davolanishdan so'ng, davolash guruhining umumiy samarali darajasi (86}}}%)%)%)%)%) ({{{{{{{{{{{{}} 5); {8}}. Davolashdan keyin PSQI ballari, Kupperman ballari va 24- {{{{{{{{{{{}}. {24}}. {24}}; Davomat guruhining halokatli guruhining zardobi nazorat guruhidan ancha yuqori bo'ldi va zarulolli gormon va lozeinizatsiya gormoni (masalan, lozinizatsiya) nazorat guruhiga qaraganda ancha past edi (p <0.05); Davolash guruhidagi salbiy reaktsiyalar bilan kasallanish (17.24%) nazorat guruhining (44,82%) dan ancha past edi; 2 haftalik kuzatuvdan so'ng, davolash guruhining qaytalanishi darajasi (10,34%) nazorat guruhi (31,03%) (p <0.05) dan ancha past bo'lgan.
Natijada Tianwang Buxin Dan, Jiaotai Wan va Minusni davolash bilan birlashtirilgan, uyqusizlik gipertenziyasini, uyqusizlik gipertenziyalarini, klinik belgilar va gormon sathi bilan bemorlarning klinik simptomlari va kam miqdorda salbiy reaktsiyalar bilan sezilarli darajada yaxshilandi. Li Yang [22] Tasodifiy ravishda menopauza qilishning buzilishi yoki yurak buyrak bilan bemorlarga g'arb tibbiyot guruhi va birlashtirilgan guruhga, har bir guruhda 49 ta ish. G'arbiy tibbiyot guruhi har kuni kechqurun yotishdan 30 daqiqa oldin, har safar 30 minut oldin Estazolam planshetlari bilan davolandi; Birlashtirilgan guruh zixin Yangshen tayyorlash bilan davolandi (har birining har biri 10 g har bir zizopogon kokinkin, zizophus officlorum, zizonumbullorum, har birining har biri Rohmaniya glutinsa, Dragon suyagi, istiridi, G'arbiy tibbiyot guruhi, kuniga ikki doz, kuniga ikki marta, kuniga ikki marta, ertalab, tong va kechqurun. 30 kunlik davolanishdan so'ng, qo'shma guruhning umumiy samarali darajasi (91,84%) G'arb tibbiyot guruhidan (75,51%) (P<0.05), and the PSQI score, Spiege sleep score, Kupperman score and TCM syndrome score of the combined group were significantly lower than those of the western medicine group (P<0.05). The results showed that the effect of estazolam tablets combined with Zixin Yangshen Decoction in treating menopausal patients with sleep disorders and heart-kidney disharmony was better.
Hu Ning [23] tasodifiy ravishda 72 menopauza qariyapti, har bir guruhda 36 ta holatga ega bo'lgan holda uyqu guruhi va davolash guruhi bilan ajralib turadi. Nazorat guruhi har kecha yotishdan oldin og'iz orqali olingan 10 mg tatarik kislota planshetlari berildi; Davolash guruhiga o'z-o'zini o'zi ishlab chiqaradigan Ziyin Xiexin tayyorlash (12' har bir Axirihisicalis, Opsiopogon Japoncus, Coptiya Xingpoi, 1 doz, ertalab va kechqurun), ertalab va kechqurun " aktoint (har safar kuniga bir marta 15 min). 4 haftalik davolanishdan so'ng, davolash guruhining umumiy samarali stavkasi (83,3%) nazorat guruhining (58,3%) (P<0.05). Professor Xiao Chengcong treated menopausal insomnia from the perspective of the heart, kidney and liver. He believed that the key to the pathogenesis of insomnia lies in the disharmony between the heart and kidney and the deficiency of liver and kidney yin. He created the Gengxin prescription (15 g each of Ligustrum lucidum, Ecliptae macrophylla, Radix Rehmanniae, Paeonia lactiflora, Fructus Lycii, Lilium, Salvia miltiorrhiza, Tribulus terrestris, Cortex Albizziae, Caulis Polygoni Multiflori, 10 g of Tribulus terrestris, 30 g each of Raw Dragon Bone and Raw Oyster, 3 g of Lotus Seed Heart, 12 g of Rhizoma Anemarrhenae) to connect the heart and kidney and nourish the kidney and liver. The prescription was adjusted according to the symptoms and the clinical efficacy was significant [24].
