1-qism: Polifenollar va vizual salomatlik: degenerativ retinal kasalliklarga potentsial ta'sir
Mar 23, 2022
Qo'shimcha ma'lumot uchun. aloqatina.xiang@wecistanche.com
Abstrakt: Parhezpolifenollarinson salomatligiga foydali ta'sir ko'rsatishi taklif qilingan tabiiy birikmalar guruhidir. Ular birinchi bo'lib o'zlari bilan tanilganantioksidantxususiyatlari, lekin yillar davomida bir necha tadqiqotlar bu birikmalar surunkali kasalliklarga qarshi himoya ta'sir ko'rsatishi mumkinligini ko'rsatdi. Shunga qaramay, ushbu potentsial imtiyozlar asosida yotgan mexanizmlar hali ham noaniq va qarama-qarshi ta'sirlar haqida xabar berilgan. Ushbu sharhda biz polifenol birikmalarining ayrim vizual kasalliklarga potentsial ta'sirini tahlil qilamiz, bunda retinal degenerativ kasalliklarga alohida e'tibor qaratamiz. Bunday retinal kasalliklarni davolash uchun hozirgi samarali davolash usullari mavjud emas va yangi strategiyalarni ishlab chiqish kerak. Shu sababli, hozirda retinal fotoretseptorlar bilan bog'lanishi va ularning molekulyar xususiyatlarini modulyatsiya qilishi mumkin bo'lgan yangi ligandlarni (yoki oldindan kutilmagan xususiyatlarga ega ma'lum ligandlarni) topishga qiziqish yangilandi. Ba'zi polifenollar, ayniqsaflavonoidlar(masalan, quercetin va tanin kislotasi) yorug'lik ta'sirida retseptorlarning shikastlanishini susaytirishi va vizual sog'liq uchun foyda keltirishi mumkin. So'nggi ma'lumotlar shuni ko'rsatadiki, ba'zi flavonoidlar rodopsinning vizual fotoreseptor oqsilining to'g'ri katlanmış konformatsiyasini barqarorlashtirishga yordam beradi va retinit pigmentoza mutatsiyalarining zararli ta'sirini bartaraf qiladi. Shu munosabat bilan, yuqorida aytib o'tilgan flavonoidlar kabi ba'zi polifenollar eksperimental in vitro tadqiqotlarida rodopsin mutantlarining barqarorligini, ifodalanishini, regeneratsiyasini va katlanishini yaxshilashi ko'rsatilgan. Bundan tashqari, bu birikmalar bir vaqtning o'zida oksidlovchi stressga qarshi ta'sir ko'rsatadigan retseptorlarning hujayra membranasiga integratsiyalashuvini yaxshilaydi. Polifenol birikmalari yaqinda taklif qilingan usulda, masalan, rodopsin kabi vizual fotoretseptor oqsillarini nishonga olish uchun ishlatilishi mumkin va ular retinitis pigmentoza kabi retinal degenerativ kasalliklarni davolashda yangi yondashuvlarda qo'llanilishini taxmin qilamiz; ammo, bu sohadagi tadqiqotlar cheklangan va taklif qilingan mexanizmlar orqali ushbu birikmalarning retinal degenerativ kasalliklarga ta'sirini to'g'ri tavsiflash uchun qo'shimcha tadqiqotlar talab etiladi.
Kalit so'zlar: flavonoidlar; retinal degenerativ kasalliklar; pigmentli retinit; oqsillarni katlama; ligandlarni bog'lash; rodopsin
Qo'shimcha mahsulotlarni o'rganish uchun shu yerni bosing
1.Kirish
Turli tadqiqotlar shuni ko'rsatdiki, parhez ovqatlanishpolifenollarneyrodegenerativ va yurak-qon tomir kasalliklari, saraton va diabet kabi surunkali kasalliklarga qarshi himoya va foydali ta'sir ko'rsatadi [1]; ammo, bu imtiyozlar asosidagi mexanizmlar to'liq tushunilmagan va ularni aniqlash uchun ko'proq tadqiqotlar talab etiladi. Polifenollarning barcha afzalliklariga qaramay, ularning fiziologik ta'sirini muhokama qilishda e'tiborga olish kerak bo'lgan ba'zi muhim jihatlar mavjud. Ushbu birikmalar og'iz orqali qabul qilinganda past bioavailabilityga ega va ularning fizik-kimyoviy barqarorligi, oshqozon-ichak traktidan so'rilishi va metabolizmi kabi boshqa xususiyatlar samarali ta'sirni ta'minlash uchun muhimdir [2,3].
Ularning harakat mexanizmida mavjud bilimlar bo'shlig'iga qaramay, Jahon sog'liqni saqlash tashkiloti o'simlikdan olingan komponentlarning ko'pligi [4] tufayli meva, sabzavot va tolani ko'paytirishni tavsiya qildi, chunki ular polifenollar muhim rol o'ynashi mumkin. yuqumli bo'lmagan kasalliklar (NCD) bilan bog'liq sog'liq uchun imtiyozlar berish [5,6]. Polifenollarni o'ziga xos kasalliklar bilan bog'lash qiyin bo'lsa-da [7], polifenollar va ba'zi NCDlar [8,9], shu jumladan ba'zi ko'rish kasalliklari bo'yicha turli kuzatuv tadqiqotlarida ba'zi istiqbolli natijalar olingan. Shu sababli, inson salomatligiga kutilayotgan ijobiy ta'sir tufayli polifenollarning salomatlik va kasallik holatidagi ta'sirini o'rganish va yaxshiroq aniqlash kerak.
Ushbu ko'rib chiqishning asosiy maqsadi polifenollarning insonning hayot sifatini yaxshilash va ayrim kasalliklarning rivojlanishini yaxshilash uchun ko'rish buzilishiga alohida e'tibor berishi mumkin bo'lgan ba'zi potentsial salomatlik foydalarining sintetik hisobini taqdim etishdir. Bu erda keng tarqalgan patologik holatlar uchun potentsial davolash usullari sifatida bir qator keng tarqalgan polifenol birikmalaridan foydalanish o'rganiladi. Bu erda biz ushbu birikmalarning ko'zning to'r pardasi faoliyatiga ta'siriga va ayniqsa, retinitis pigmentoza (RP) kabi retinal degenerativ kasalliklar bilan bog'liq bo'lgan retinal oqsil mutatsiyalariga qarshi potentsial foydalanishga e'tibor qaratamiz. Ularning fiziologik ahamiyatini ochib berish uchun ko'proq klinik sinovlarga ehtiyoj bor, chunki polifenollarning inson ko'rish qobiliyatiga ta'siri bo'yicha faqat oz sonli tadqiqotlar o'tkazildi va ularning natijalari qo'shimcha tasdiqlashni talab qiladi.
2. Usullar
Ushbu maqola polifenollarning ba'zi vizual kasalliklarga ta'siri, ayniqsa ularning retinal degenerativ kasalliklariga ta'siri haqida adabiyot sharhidir. Yillar davomida polifenollarga berilgan yangi xususiyatlarni hisobga olgan holda, bizning tadqiqotimizning asosiy maqsadi bu birikmalar insonning ko'rish salomatligiga ijobiy ta'sir ko'rsatishi mumkinligini ko'rsatish va tadqiqotchilarni ushbu sohaga qiziqishga undashdir. Ushbu sharhdagi turli tadqiqotlar (tasodifiy nazorat sinovlari, meta-tahlil, sharhlar va eksperimental va kuzatuv tadqiqotlari) PubMed va Cochrane maʼlumotlar bazalarini 2021-yilning fevraligacha va shu jumladan, qidirish orqali aniqlangan. Tibbiy mavzu boʻyicha quyidagi kalit soʻzlardan foydalanilgan: “polifenollar "," flavonoidlar ", "retina degenerativ kasalliklari" va "retinit pigmentoza". Tegishli maqolalar ikkita muallif tomonidan qo'shilish mezonlariga, ya'ni ingliz tilida yozilgan asl to'liq matnli maqolalarga (shu jumladan klinik va preklinik tadqiqotlar) rioya qilgan holda aniqlandi va mustaqil ravishda tanlandi. Boshqa tomondan, istisno qilish mezonlariga ingliz tilidan boshqa tillarda yozilgan maqolalar va maqolalar kiritilgan.
3. Polifenollar qayta ishlatiladigan dorilar sifatida
Polifenollar yoki parhez fenolik birikmalar fitokimyoviylarning eng katta guruhi sifatida tanilgan [10] va umumiy tuzilish xususiyatlariga ega bo'lgan tabiiy birikmalar guruhidir (1-rasm). Hozirgi vaqtda inson salomatligi va kasallik holatlari bilan bog'liq potentsial rollar tufayli tabiiy birikmalarning ushbu keng oilasiga qiziqish kuchaymoqda. So‘nggi bir necha yildagi doimiy ishlar natijasida olingan turli dalillar polifenollarning sog‘lom turmush tarzini saqlashda hamda saraton, yurak-qon tomir va neyrodegenerativ kasalliklar kabi keng tarqalgan kasalliklarning oldini olishda muhim rol o‘ynashini qo‘llab-quvvatlaydi [11-13 ]. Xususan, bir nechta tadqiqotlar shuni ko'rsatdiki, meva va sabzavotlar kabi tabiiy manbalardan turli xil polifenollarni iste'mol qilish ko'rishni saqlab qolishga hissa qo'shishi va hatto ba'zi ko'rish kasalliklarida ko'rish buzilishini bartaraf etishi mumkin [14,15].
![es of representative and abundant polyphenols from different subfamilies. Quercetin is a typical flavonoid found in many products. Resveratrol is a natural polyphenolic phytoalexin. Curcumin is derived from the rhizome of turmeric and is usually found in its keto form. Finally, daidzein is one of the most common isoflavones. The polyphenol superfamily includes a large number of sub-families, among which we can find flavonoids, phenolic acids, stilbenes, and lignans [16]. In fact, they constitute a group of natural products in the plant kingdom that is one of the most numerous and ubiquitously distributed. One of the most studied groups, from these different sub-classes, is that of flavonoids, comprising over 4000 members [17]. Flavonoids have a characteristic structure of a 15-carbon skeleton of a chromane ring attached to another aromatic ring [18]. The biosynthesis of these complex polyphenols is linked to primary metabolism [10]. Flavonoids are stored, in their native state, in plants as glycoside and non-glycosylated conjugates and can be absorbed by the small intestine and readily metabolized, once ingested, by phase II enzymes. After this biochemical process, the resulting moieties can enter systemic circulation [19,20]. It should be noted that not all flavonoids are absorbed by the small intestine. A large number of them enter the large intestine, where the deconjugated metabolites are degraded by the colonic microbiota into molecules like phenolic acids that can be easily absorbed [19]. One of the main proposed biological actions of polyphenols is associated with their antioxidant power within living cells; however, detailed investigations indicate that these effects, in many tissues, may not be as relevant as previously suggested. This is due to the fact that in many tissues it is difficult for these compounds to reach the threshold concentration needed to exert any significant biological effect [21,22]. Nonetheless, recent studies have suggested that polyphenols may have significant effects on human health, such as anti-inflammatory, anti-microbial, and tumor-suppressing properties [23–25]. The diversity of polyphenolic compounds of natural origin, their chemical lability, and their complex bioavailability patterns consequently necessitates stringent evaluation of the physiological effects of these compounds, and such evaluations are not always available. These evaluations are absolutely needed for later use in therapeutic applications. 4. Implications and Potential Benefits of Polyphenols on Human Health As already discussed, polyphenols have been well characterized for their antioxidant effects, but their physiological relevance has been questioned due to the limited bioavailability that renders relatively low concentrations which may hamper achieving significant Figure 1. Structures of representative and abundant polyphenols from different subfamilies. Quercetin is a typical flavonoid found in many products. Resveratrol is a natural polyphenolic phytoalexin. Curcumin is derived from the rhizome of turmeric and is usually found in its keto form. Finally, daidzein is one of the most common isoflavones](/Content/uploads/2022842169/20220323103717b1b02e19a56a4000a29040e34368b70b.png "es of representative and abundant polyphenols from different subfamilies. Quercetin is a typical flavonoid found in many products. Resveratrol is a natural polyphenolic phytoalexin. Curcumin is derived from the rhizome of turmeric and is usually found in its keto form. Finally, daidzein is one of the most common isoflavones. The polyphenol superfamily includes a large number of sub-families, among which we can find flavonoids, phenolic acids, stilbenes, and lignans [16]. In fact, they constitute a group of natural products in the plant kingdom that is one of the most numerous and ubiquitously distributed. One of the most studied groups, from these different sub-classes, is that of flavonoids, comprising over 4000 members [17]. Flavonoids have a characteristic structure of a 15-carbon skeleton of a chromane ring attached to another aromatic ring [18]. The biosynthesis of these complex polyphenols is linked to primary metabolism [10]. Flavonoids are stored, in their native state, in plants as glycoside and non-glycosylated conjugates and can be absorbed by the small intestine and readily metabolized, once ingested, by phase II enzymes. After this biochemical process, the resulting moieties can enter systemic circulation [19,20]. It should be noted that not all flavonoids are absorbed by the small intestine. A large number of them enter the large intestine, where the deconjugated metabolites are degraded by the colonic microbiota into molecules like phenolic acids that can be easily absorbed [19]. One of the main proposed biological actions of polyphenols is associated with their antioxidant power within living cells; however, detailed investigations indicate that these effects, in many tissues, may not be as relevant as previously suggested. This is due to the fact that in many tissues it is difficult for these compounds to reach the threshold concentration needed to exert any significant biological effect [21,22]. Nonetheless, recent studies have suggested that polyphenols may have significant effects on human health, such as anti-inflammatory, anti-microbial, and tumor-suppressing properties [23–25]. The diversity of polyphenolic compounds of natural origin, their chemical lability, and their complex bioavailability patterns consequently necessitates stringent evaluation of the physiological effects of these compounds, and such evaluations are not always available. These evaluations are absolutely needed for later use in therapeutic applications. 4. Implications and Potential Benefits of Polyphenols on Human Health As already discussed, polyphenols have been well characterized for their antioxidant effects, but their physiological relevance has been questioned due to the limited bioavailability that renders relatively low concentrations which may hamper achieving significant Figure 1. Structures of representative and abundant polyphenols from different subfamilies. Quercetin is a typical flavonoid found in many products. Resveratrol is a natural polyphenolic phytoalexin. Curcumin is derived from the rhizome of turmeric and is usually found in its keto form. Finally, daidzein is one of the most common isoflavones")
Polifenol superfamiliyasi ko'p sonli kichik oilalarni o'z ichiga oladi, ular orasida flavonoidlar, fenolik kislotalar, stilbenlar va lignanlarni topishimiz mumkin [16]. Aslida, ular o'simliklar shohligidagi eng ko'p va hamma joyda tarqalgan tabiiy mahsulotlar guruhini tashkil qiladi. Ushbu turli kichik sinflardan eng ko'p o'rganilgan guruhlardan biri bu 4000 dan ortiq a'zolarni o'z ichiga olgan flavonoidlardir [17].Flavonoidlarboshqa aromatik halqaga biriktirilgan xroman halqasining uglerod skeletining 15- xarakterli tuzilishiga ega [18]Bu murakkab polifenollarning biosintezi birlamchi metabolizm bilan bogʻliq [10]. Flavonoidlar o'simliklarda glikozidlar va glikozillanmagan konjugatlar shaklida saqlanadi va ingichka ichakda so'riladi va yutilgandan so'ng I faza fermentlari tomonidan osongina metabollanadi. Ushbu biokimyoviy jarayondan so'ng hosil bo'lgan qismlar tizimli qon aylanishiga kirishi mumkin [19,20].
Shuni ta'kidlash kerakki, barcha flavonoidlar ingichka ichak tomonidan so'rilmaydi. Ularning katta qismi yo'g'on ichakka kiradi, bu erda dekonjugatsiyalangan metabolitlar yo'g'on ichak mikrobiotasi tomonidan oson so'rilishi mumkin bo'lgan fenolik kislotalar kabi molekulalarga parchalanadi [19].
Polifenollarning asosiy tavsiya etilgan biologik harakatlaridan biri ularning tirik hujayralardagi antioksidant kuchi bilan bog'liq; ammo, batafsil tadqiqotlar shuni ko'rsatadiki, ko'p to'qimalarda bu ta'sirlar ilgari taklif qilinganidek ahamiyatli bo'lmasligi mumkin. Buning sababi shundaki, ko'pgina to'qimalarda bu birikmalar har qanday muhim biologik ta'sir ko'rsatish uchun zarur bo'lgan chegara konsentratsiyasiga erishish qiyin [21,22]. Shunga qaramay, yaqinda o'tkazilgan tadqiqotlar shuni ko'rsatdiki, polifenollar inson salomatligiga sezilarli ta'sir ko'rsatishi mumkin, masalan, yallig'lanishga qarshi, mikroblarga qarshi va o'smalarni bostiruvchi xususiyatlar [23-25]. Tabiiy kelib chiqadigan polifenol birikmalarining xilma-xilligi, ularning kimyoviy labilligi va murakkab bioavailability naqshlari, shuning uchun bu birikmalarning fiziologik ta'sirini qat'iy baholashni talab qiladi va bunday baholashlar har doim ham mavjud emas. Ushbu baholashlar keyinchalik terapevtik dasturlarda foydalanish uchun mutlaqo zarurdir.
4. Polifenollarning inson salomatligiga ta'siri va potentsial foydalari
Yuqorida aytib o'tilganidek, polifenollar antioksidant ta'siri uchun yaxshi tavsiflangan, ammo ularning fiziologik ahamiyati cheklangan bioavailability tufayli so'roq qilingan, bu nisbatan past konsentratsiyalarni keltirib chiqaradi, bu esa sezilarli in vivo ta'sirga erishishga to'sqinlik qilishi mumkin [21,22]; ammo, polifenollar rol o'ynaydigan turli xil alternativ molekulyar mexanizmlar aniqlangan va bu ushbu birikmalarni beradi.
inson salomatligi uchun foydani ifodalashi mumkin bo'lgan boshqa xususiyatlar to'plami. Bular hujayra ichidagi va hujayralararo signalizatsiya yo'llari darajasida turli xil harakatlarni o'z ichiga oladi, masalan, yadro transkripsiyasi omillari va yog 'almashinuvini tartibga solish va sitokinlar, o'simta nekrozi omili x, interleykin kabi yallig'lanish vositachilari sintezini modulyatsiya qilish-1 , va interleykin-6 [26,27]. Umumiy nuqtai nazar sifatida, turli o'rganilgan flavonoidlar hujayra jarayonlarida insulin sekretsiyasini oshirish, apoptozni kamaytirish, hujayralar ko'payishini rag'batlantirish va ayrim hujayralardagi yallig'lanish va oksidlovchi stressni kamaytirish kabi turli xil rollarni o'ynashi ko'rsatilgan [28]. Bu ta'sirlarning barchasi glyukoregulyatsiya kabi turli jarayonlarda rol o'ynaydi va flavonoidlar diabet va semirishning oldini olish va nazorat qilishda ijobiy ta'sir ko'rsatishi mumkinligini ko'rsatadi [29-31].
Bugungi kunga qadar taklif qilingan polifenollarning barcha mumkin bo'lgan foydali ta'siriga qaramasdan, ko'rib chiqilishi kerak bo'lgan asosiy jihat bu birikmalarning inson tanasida samarali kontsentratsiyasi va bunday konsentratsiyaga erishish uchun iste'mol qilinishi kerak bo'lgan tabiiy oziq-ovqat miqdori bilan bog'liq. Ko'pgina hollarda, ma'lum bir fiziologik funktsiyani amalga oshirish uchun zarur bo'lgan polifenol miqdoriga oddiy oziq-ovqat mahsulotlarini tegishli miqdorda oddiy dietada iste'mol qilish orqali erishish mumkin va bunday hollarda zaharlanishning oldini oladi. Potentsial foydali ta'sirlarni oldindan ko'rish mumkin bo'lgan boshqa hollarda, polifenol o'z ichiga olgan oziq-ovqat mahsulotlarini iste'mol qilishni oshirish kerak va printsipial jihatdan, agar bu o'sish ehtiyotkorlik bilan rejalashtirilgan bo'lsa, hech qanday salbiy ta'sir kutilmaydi. Nihoyat, agar fiziologik faol kontsentratsiyaga umumiy oziq-ovqat iste'mol qilish bilan erishib bo'lmasa, unda parhez qo'shimchalari yoki farmakologik yondashuvlar zarur bo'lishi mumkin. Bu nojo'ya ikkilamchi ta'sirlarning kuchayishiga olib kelishi mumkin, bu esa qabul qilishni qat'iy kuzatish va doza rejimini to'g'ri nazorat qilishni talab qiladi [30].
Polifenollar asosan qahva, choy, kakao va olma kabi turli xil oziq-ovqat manbalarini iste'mol qilish orqali ta'minlanadi va ular sog'liq uchun bir qancha potentsial foydalar bilan bog'liq [56,11,14,32-36]. Aslida, polifenollar glyukoza metabolizmi, trombotsitlar funktsiyasi, endotelial funktsiya, qon bosimi, yallig'lanish va xolesterin darajasida va boshqalarda mexanik ravishda ishtirok etgan [37,38]. Polifenollar ta'sirida ta'sir qilishi mumkin bo'lgan hujayra funktsiyalarining xilma-xilligi nafaqat keng tarqalgan NCDlar uchun, balki genetik irsiy kam uchraydigan patologik holatlar uchun ham sog'liqni saqlashning samarali oldini olish strategiyalarini, shuningdek, yangi terapevtik yondashuvlarni ishlab chiqish uchun ajoyib platformadir [5,6] . Polifenollarning inson salomatligiga foydali ta'siriga oid ba'zi dalillar kuzatuv tadqiqotlaridan kelib chiqadi va bu eksperimental ma'lumotlarni sharhlashda mazmunli xulosalar chiqarishda bir nechta omillarni hisobga olishni nazarda tutadi. Misol uchun, turli xil oziq-ovqatlardan polifenollarni ko'p iste'mol qilish hayvonlardan kelib chiqadigan, zararli bo'lishi mumkin bo'lgan oziq-ovqatlarni kamaytirish bilan muvozanatlashtirilishi mumkin; biroq, kuzatuv tadqiqotlari ko'p hollarda, masalan, keyinchalik nazorat qilinadigan aralashuv tadqiqotlariga kiritiladigan gipotezalarni shakllantirishda foydali bo'lishi mumkin. Aslida, ushbu masala bo'yicha kuzatuv tadqiqotlari dietali fenolik moddalarning inson salomatligini yaxshilash va kasalliklarning oldini olishda ijobiy rol o'ynashi haqidagi farazni baholaydigan jiddiy va keng klinik tadqiqotlar bilan to'ldirilishi va qo'llab-quvvatlanishi kerak [28].
Kardiyometabolik salomatlikka barcha ta'sirlardan tashqari, polifenollar ham kognitiv funktsiyada foydali rolga ega. Misol uchun, ba'zi uzunlamasına tadqiqotlar shuni ko'rsatadiki, shokoladni muntazam ravishda iste'mol qilish kognitiv pasayish xavfini kamaytirishi mumkin 39,40. Choy kabi boshqa oziq-ovqat manbalarini o'rganish shuni ko'rsatadiki, uni iste'mol qilish kognitiv buzilish xavfini kamaytirishga yordam beradi, depressiya xavfini kamaytiradi va Parkinson kasalligi [41-44] kabi ba'zi kasalliklarga qarshi himoya ta'siriga ega.
Barcha polifenol turlaridan parhez flavonoidlari retinit pigmentoza kabi retinal degenerativ kasalliklarda ham foydali ta'sir ko'rsatishi mumkin, bu erda retinal oqsillardagi mutatsiyalar fotoreseptor hujayralarining o'limiga va ko'rishning yo'qolishiga olib kelishi mumkin, natijada ko'rlikka olib keladi. Aslida, flavonoid quercetin vizual G oqsili bilan bog'langan retseptorlari (GPCR) rodopsin (Rho) [45] ning konformatsion barqarorligi va funktsiyasiga ta'sir ko'rsatishi aniqlandi. Ushbu natijalar quercetin G90V Rho RP mutantining barqarorligi va konformatsion xususiyatlariga ijobiy ta'sir ko'rsatishi mumkinligini ko'rsatadi. Ushbu natijalar flavonoidlar va boshqa polifenollar uchun o'rnatilgan antioksidant ta'sirga qo'shimcha ravishda boshqa rollar ham nazarda tutilishi mumkinligini ta'kidlaydi. Retinal Rhoga ta'siri qo'shimcha tekshirishga loyiq bo'lgan retseptorlar darajasida ta'sir ko'rsatadi. Ushbu natijalar RP bilan bog'liq retinal degeneratsiyani davolash uchun ushbu va boshqa flavonoidlarni, ehtimol o'ziga xos retinoidlar bilan birgalikda ishlatish uchun yangi imkoniyatlarni ochadi. Ushbu strategiya GPCR superoilasining boshqa a'zolarida turli patologik sharoitlar bilan bog'liq mutatsion ta'sirni bartaraf etish uchun ham qo'llanilishi mumkin [45].
Polifenolik birikmalar, xususan, flavonoidlar sog'lom turmush tarzining bir qismi sifatida qabul qilingan antioksidant salohiyatidan tashqari, inson kasalliklarini davolash yoki rivojlanishini yaxshilash uchun yaxshi istiqboldir.
